Jeffrey Weber, MD, PhD, NYU Langone Medical Center, New York, NY, outlines a debate about wether radiotherapy elicits an abscopal effect where the shrinkage of untreated tumors takes place concurrently with shrinkage of the targeted tumor during local therapy. Dr Weber argues that radiotherapy does not elicit an abscopal effect. This interview took place during the 10th World Congress of Melanoma in conjunction with the 17th EADO Congress Interactive Virtual Meeting.