ASCO 2024 | Promising targets in ADCs for breast cancer
Erika Hamilton, MD, from the Sarah Cannon Research Institute in Nashville, TN, discusses the evolving landscape of antibody drug conjugates (ADCs) in breast cancer treatment. Currently, ADCs such as trastuzumab emtansine, trastuzumab deruxtecan, and sacituzumab govitecan are approved for HER2-positive breast cancer. Dr Hamilton anticipates the approval of datopotamab deruxtecan, another ADC targeting TROP-2, in the near future. Additionally, she highlights the diverse range of targets being explored for ADC development, including b7-h4, claudin, and HER3. Notably, HER3-targeted ADCs do not require testing for HER2 status, offering potential benefits across various breast cancer subtypes. This discussion underscores the expanding therapeutic options in breast cancer treatment and the potential of ADCs to address unmet medical needs across multiple breast cancer types. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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Disclosures
Consulting or Advisory Role – Accutar Biotechnology; AstraZeneca; Daiichi Sankyo; Ellipses Pharma; Entos; Fosun Pharma; Genentech/Roche; Gilead Sciences; Jazz Pharmaceuticals; Jefferies; Lilly; Medical Pharma Services; Mersana; Novartis; Olema Pharmaceuticals; Pfizer; Stemline Therapeutics; Tempus; Theratechnologies; Tubulis GmbH; Verascity Science; Zentalis
Research Funding – Abbvie; Accutar Biotech; Acerta Pharma; ADC Therapeutics; Akeso Biopharma; Amgen; Aravive; ArQule; Artios; Arvinas; AstraZeneca; AtlasMedx; BeiGene; Black Diamond Therapeutics; Bliss Biopharmaceutical; Boehringer Ingelheim; Bristol-Myers Squib; Cascadian Therapeutics; Clovis Oncology; Compugen; Context Therapeutics; Cullinan Oncology; Curis; CytomX Therapeutics; Daiichi Sankyo; Dana Farber Cancer Hospital; Dantari; Deciphera; Duality Biologics; eFFECTOR Therapeutics; Eisai; Ellipses Pharma; Elucida Oncology; EMD Serono; Fochon Pharmaceuticals; Fujifilm; G1 Therapeutics; Genentech/Roche; Gilead Sciences; H3 Biomedicine; Harpoon; Hutchison MediPharma; Immunogen; Immunomedics; Incyte; Infinity Pharmaceuticals; Inspirna; InventisBio; Jacobio; K-Group Beta; Karyopharm Therapeutics; Kind Pharmaceuticals; Leap Therapeutics; Lilly; Loxo; Lycera; MabSpace Biosciences; Macrogenics; MedImmune; Mersana; Merus; Millennium; Molecular Templates; Myriad Genetics; Novartis; Nucana; Olema Pharmaceuticals; OncoMed; Onconova Therapeutics; Oncothyreon; ORIC Pharmaceuticals; Orinove; Orum Therapeutics; Pfizer; PharmaMar; Pieris Pharmaceuticals; Pionyr; Plexxikon; Prelude Therapeutics; ProfoundBio; Radius Health; Regeneron; Relay Therapeutics; Repertoire Immune Medicines; Rgenix; Seagen; Sermonix Pharmaceuticals; Shattuck Labs; Silverback Therapeutics; Stem CentRx; Stemline Therapeutics; Sutro Biopharma; Syndax; Syros Pharmaceuticals; Taiho Pharmaceutical; TapImmune Inc.; Tesaro; Tolmar; Torque; Treadwell Therapeutics; Verastem; Zenith Epigenetics; Zymeworks
