Lion Shahab, MSc, PhD, CPsychol, AFBPsS, PGCLTHE, from University College London, London, UK, discusses the regulatory and safety considerations that need to be made as new harm reduction products for cigarette smokers are developed and introduced. Increasing options available may also lead to a reduction in the numbers of cigarette smokers in the long run, suggests Dr Shahab from the 2018 National Cancer Research Institute (NCRI) Cancer Conference, held in Glasgow, UK.