Elizabeth Plimack, MD, MS, Fox Chase Cancer Center, Philadelphia, PA, outlines areas of unmet need for patients with advanced urothelial carcinoma (UC) including understanding mechanisms of resistance and lack of response in patients treated with immune checkpoint blockade. Dr Plimack also highlights the importance of identifying treatment regimens with a more tolerable safety profile, especially within the metastatic setting. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.