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ASCO 2022 | MAINTAIN: fulvestrant or exemestane +/- ribociclib after anti-estrogen therapy + CDK4/6i in HR+ MBC

CDK4/6 inhibition has previously shown significant benefit in progression-free survival (PFS) in patients with HR-positive, HER2-negaitve metastatic breast cancer (mBC). Switching anti-estrogen therapies following disease progression is the standard of care (SOC) for this patient population. Kevin Kalinsky, MD, MS, Winship Cancer Institute of Emory University, Atlanta, GA, talks on the randomized, multicentered, double-blind, placebo-controlled Phase II MAINTAIN (NCT02632045) trial investigating fulvestrant or exemestane with or without ribociclib after progression on anti-estrogen therapy plus cyclin-dependent kinase 4/6 inhibition in patients with unresectable or HR-positive, HER2-negative metastatic breast cancer (mBC). This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.

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