Tian Zhang, MD, Duke Cancer Center, Durham, NC, discusses the possible impact of androgen deprivation therapy (ADT) on COVID-19 patients with prostate cancer. The androgen-regulated gene TMPRSS2 has been implicated in SARS-CoV-2 viral entry, and therefore ADT was hypothesized to potentially improve COVID-19 outcomes. Across 1005 individuals from the CCC19 analysis, 879 of whom were included in a mortality analysis, no association was found between ADT and improved COVID-19 outcomes in patients with prostate cancer. Further investigations are still on-going. This interview took place during the 2021 Genitourinary Cancers Symposium.