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NACLC 2022 | Tumor mutation burden as a biomarker in NSCLC

Biagio Ricciuti, MD, Dana-Farber Cancer Institute, Boston, MA, comments on the role of tumor mutational burden (TMB) as biomarker in non-small cell lung cancer (NSCLC). Due to the heterogeneity of tumors that will have varying TMB, a pan-tumor threshold may lead to inaccurate results. Studies have alternatively shown a link between a high TMB and higher progression-free survival when receiving immunotherapy, which may be due to higher immunogenicity in these patients. TMB has additionally found to be independent of PD-L1 status, emphasizing the need to personalize treatment across subgroups. This interview took place at the IASLC 2022 North America Conference on Lung Cancer (NACLC 2022).

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Biagio Ricciuti, MD, is a consultant/advisory board for Regeneron.