Guru Sonpavde, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the results of a retrospective analysis investigating the impact of angiotensin blockade on response to PD1/L1 inhibitors for patients with metastatic urothelial carcinoma (mUC). The study analyzed data from 178 patients with mUC who had received PD1/L1 inhibitor therapy. The results demonstrated that patients who had received angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) had greater tumor regression and improved overall survival (OS). This interview took place during the 2021 Genitourinary Cancers Symposium.