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BCC 2025 | Unanswered questions in managing HER2- early-stage breast cancer

Kevin Kalinsky, MD, MS, Emory University Hospital, Atlanta, GA, comments on the nuances of treating hormone receptor-positive HER2-negative early-stage breast cancer, highlighting the importance of considering geographic variability in treatment approaches and the ongoing debate about the role of ovarian function suppression in postmenopausal patients, particularly those under 40 years of age. CDK4/6 inhibitors offer benefit, but chemotherapy remains a common treatment approach. This interview took place at the 2025 St. Gallen International Breast Cancer Consensus Meeting in Vienna, Austria.

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