Brain metastases are associated with high disease morbidity and mortality rates. Rupert Bartsch, MD, Medical University of Vienna, Vienna, Austria, talks on systemic therapy for the treatment of brain metastases, which are now known to be effective, including tucatinib and trastuzumab deruxtecan. This interview took place at the European Society for Medical Oncology (ESMO) Breast Cancer 2022 congress in Berlin, Germany.