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AACR 2025 | The benefits of combined biopsies in advanced solid tumors

Paolo Marchetti, MD, PhD, IDI-IRCCS, Rome, Italy, discusses the potential of combining biopsy data with additional omics layers to provide holistic tumor characterization. These new techniques enable the integration of radiomics, proteomics, transcriptomics, and metabolomics with genomic data, as demonstrated in the ROME trial (NCT04712864). Advanced machine learning techniques can also extract meaningful patterns from integrated omics data sets, allowing for more precise therapeutic targeting. This interview took place at American Association for Cancer Research (AACR) Annual Meeting 2025 in Chicago, IL.

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Transcript

Rather than being reserved only for a specific clinical context, the combined biopsy approach appears to have a broad role in the advanced tumor treatment landscape, with particular value in cases with multiple metastases or high tumor fraction or when targeting specific molecular pathways. The ROM trial provides strong evidence that integrating tissue and liquid biopsies enhances the precision of cancer diagnostics and treatment outcomes in advanced solid tumors...

Rather than being reserved only for a specific clinical context, the combined biopsy approach appears to have a broad role in the advanced tumor treatment landscape, with particular value in cases with multiple metastases or high tumor fraction or when targeting specific molecular pathways. The ROM trial provides strong evidence that integrating tissue and liquid biopsies enhances the precision of cancer diagnostics and treatment outcomes in advanced solid tumors. As technology advances and costs potentially decrease, combined biopsies are likely to become increasingly integrated into standard oncology practice. Thank you.

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