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WCLC 2025 | How do you determine who with lung cancer is unfit for chemo-RT?
Andrea Filippi, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, discusses the criteria for whether a patient with lung cancer is unfit for concurrent chemoradiotherapy. Evaluating comorbidities, particularly heart and lung conditions, in patients is important, as they can impact tolerance to chemotherapy and other treatments. A multidisciplinary approach is needed, as well as collaboration with cardiologists and pulmonologists to assess patients with complex cases. This interview took place at 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain.
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Transcript
No, age itself is not the main issue. Most of the time we look at the comorbidities, especially heart and lung comorbidities, because it’s very difficult to tolerate chemotherapy and also other systemic agents if you have metabolic problems or heart disease etc. Even if you can do a multidisciplinary evaluation and we discuss a lot because sometimes things are not black and white...
No, age itself is not the main issue. Most of the time we look at the comorbidities, especially heart and lung comorbidities, because it’s very difficult to tolerate chemotherapy and also other systemic agents if you have metabolic problems or heart disease etc. Even if you can do a multidisciplinary evaluation and we discuss a lot because sometimes things are not black and white. We have some patients that are, I have to say, borderline fits and so it’s really something you need to discuss also with cardiologists, with pulmonologists, so there are many clinical factors. It’s not an easy assessment.
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