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AACR 2023 | Zanidatamab and chemotherapy in HER2+ gastroesophageal cancer

Geoffrey Ku, MD, Memorial Sloan Kettering Cancer Center, New York, NY, provides an overview of results from a Phase II trial (NCT03929666) assessing zanidatamab, an anti-HER2 pleotropic bispecific antibody, with chemotherapy in patients with HER2-positive gastroesophageal adenocarcinoma. Patients received the investigational therapy and a diarrheal prophalxis with a choice of FOLFOX, or capecitabine with cisplatin. A high response rate was reported, with a duration of response over 20 months. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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