WCCS 2022 | Dermoscopy and genetics in skin cancer

Susana Puig Sardá, MD, PhD, Hospital Clínic Barcelona, Barcelona, Spain, discusses dermoscopy and genetics in skin cancer. More than 50% of the risk of developing melanoma depends on genetic susceptibility. This genetic susceptibility is associated with clinical and phenotypic characteristics of the patients and their tumors. Notably, MC1R polymorphism can determine clinical and dermoscopic characteristics of the nevus and tumors. A comparative approach was analyzed in patients with multiple nevi and melanoma in patients with two MC1R polymorphisms revealing a number of false negatives due to the similarity of melanomas to nevi. Dr Sardá additionally provides an overview on MITF, BAP1 and hereditary mutations in POT1 and telomere genes in melanoma. This interview took place at the 18th World Congress on Cancers of the Skin (WCCS 2022) in Buenos Aires, Argentina.

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