Neil J. Shah, MBBS, Memorial Sloan Kettering Cancer Center, New York City, NY, discusses real-world clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) in current immune-oncology (IO) and tyrosine kinase inhibitors (TKIs) era. This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.