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ASCO 2025 | Strategies to overcome barriers in cancer vaccine efficacy

Margaret Gatti-Mays, MD MPH, The Ohio State University, Columbus, OH, comments on the current limitations of cancer vaccines and the emerging strategies to address them, highlighting three key platforms: DNAJB1-PRKACA fusion-based, SYNC-T in situ, and oral vaccines. She notes that they collectively draw into question whether the generation of a first immune response in patients and subsequent immunotherapy is a potential strategy. This interview took place at the 2025 American Society of Clinical Oncology (ASCO) meeting in Chicago, IL.

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