ASCO 2023 | Triple PD-1, LAG-3 and TIM-3 inhibition in solid tumors

Omid Hamid, MD, The Angeles Clinic and Research Institute, Los Angeles, CA, comments on results from a Phase I/II trial (NCT04370704) of retifanlimab, INCAGN02385, and INCAGN02390 in patients with advanced solid tumors. Combining anti-PD-1, LAG-3 and TIM-3 therapies was found to benefit patients, where the regimen was well tolerated in pretreated patients, and no novel toxicities were reported. Further research will assess this combination in the first-line setting in patients with treatment-naïve melanoma. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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