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ASCO GI 2025 | Post-osimertinib landscape for NSCLC

Alexander Spira, MD, PhD, Virginia Cancer Specialist, Fairfax, VA, comments on the complexity of the post-osimertinib space in non-small cell lung cancer (NSCLC), noting the resurgence of other drugs and the development of new targeted therapies, including antibody-drug conjugates (ADCs) such as patritumab deruxtecan and bispecific antibodies, as well as ongoing studies targeting C797S resistance. This interview took place at the ASCO GI Cancers Symposium 2025 in San Francisco, CA.

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