Elizabeth Plimack, MD, MS, Fox Chase Cancer Center, Philadelphia, PA, explores the findings of a single-center analysis of exceptional responders to cancer therapy from the Fox Chase Cancer Center. In this study, mutations in DNA damage repair pathway genes were frequently present in exceptional responders, suggesting a role of increased genomic instability which may have contributed to exceptional responses to standard anticancer therapies in the patients studied. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.